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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm5.1Fwa
targeted mutation 5.1, Frederick W Alt
MGI:5295440
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm5.1Fwa/Ightm5.1Fwa involves: 129S6/SvEvTac MGI:5295456
ht2
 		Ightm5.1Fwa/Igh+ involves: 129S6/SvEvTac MGI:5295457


Genotype
MGI:5295456
hm1
Allelic
Composition		 Ightm5.1Fwa/Ightm5.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm5.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176649 )
N
• mice exhibit normal B cell populations in the bone marrow and spleen
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
decreased pre-B cell number ( J:176649 )
• in the bone marrow

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
decreased pre-B cell number ( J:176649 )
• in the bone marrow




Genotype
MGI:5295457
ht2
Allelic
Composition		 Ightm5.1Fwa/Igh+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm5.1Fwa mutation (0 available); any Igh mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176649 )
N
• mice exhibit normal B cell populations in the bone marrow and spleen
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
decreased pre-B cell number ( J:176649 )
• in the bone marrow

hematopoietic system
abnormal B cell differentiation ( J:176649 )
• mice exhibit a reduction in the ratio of pre-B to pro-B cells compared with wild-type mice
decreased pre-B cell number ( J:176649 )
• in the bone marrow




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory