Allele Symbol Allele Name Allele ID |
Sirt2tm1.1Auw targeted mutation 1.1, Johan Auwerx MGI:5295483 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit a transient delay in myelination compared with wild-type mice
• the sciatic nerve is hypomyelinated at P1, P3, and P5
• at P21 and P28, mice exhibit extensive outfoldings in compact myelin located in close vicinity to the paranode
• following nerve crush injury, mice exhibit reduced myelination compared with wild-type mice
• however, mice exhibit normal myelination at P7 and remyelination following nerve crush injury after 28 days
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• at P21 and P28
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• remyelination following nerve crush injury is delayed compared to in wild-type mice
• however, axon regeneration is normal
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N |
• mice exhibit normal function on a rotarod, grip strength, and thermal nociception
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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