Phenotypes associated with this allele

• Allele Symbol: Zc3h12a^tm1Fum
• Allele Name: targeted mutation 1, Mingui Fu
• Allele ID: MGI:5295981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zc3h12a^tm1Fum/Zc3h12a^tm1Fum	C57BL/6-Zc3h12a^tm1Fum	MGI:5295987

Genotype
MGI:5295987

hm1

• Allelic Composition: Zc3h12a^tm1Fum/Zc3h12a^tm1Fum
• Genetic Background: C57BL/6-Zc3h12a^tm1Fum

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:176866 )

immune system

enlarged spleen ( J:176866 )

abnormal circulating chemokine level ( J:176866 )

• MCP-1 levels are increased greater than 2.5 times

increased circulating tumor necrosis factor level ( J:176866 )

• greater than 2.5 times

enlarged lymph nodes ( J:176866 )

abnormal chemokine secretion ( J:176866 )

• unstimulated or LPS-stimulated bone marrow derived macrophage exhibit increased MCP-1 secretion compared with wild-type cells

increased interleukin-1 beta secretion ( J:176866 )

• from unstimulated or LPS-stimulated bone marrow derived macrophage

increased interleukin-6 secretion ( J:176866 )

• from unstimulated or LPS-stimulated bone marrow derived macrophage

increased tumor necrosis factor secretion ( J:176866 )

• from unstimulated or LPS-stimulated bone marrow derived macrophage

homeostasis/metabolism

abnormal circulating chemokine level ( J:176866 )

• MCP-1 levels are increased greater than 2.5 times

increased circulating tumor necrosis factor level ( J:176866 )

• greater than 2.5 times

growth/size/body

postnatal growth retardation ( J:176866 )

• after weaning

enlarged spleen ( J:176866 )

hematopoietic system

enlarged spleen ( J:176866 )