Analysis Tools
mortality/aging
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• when animals are implanted with a minipump delivering gancyclovir, mice become morbid after a week, and die within another weak
• Note: Mice become morbid after gancyclovir treatment for a week. If treatment is stopped, gradual recovery of animals over subsequent weeks is observed; umbers of Sox2-positive cells increase after 7 days and tongue, esophagus, and forestomach tissue examination show normal epithelialization of tissues with intact basal and differentiated cell layers.
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cellular
growth/size/body
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• mice treated with gancyclovir for more than 7 days appear smaller in size than controls (possibly due to dehydration and problem with food absorption)
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reproductive system
small testis
(
J:177655
)
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• 3 months following end of a 1-week gancyclovir treatment of 3- or 7-week old mice, testes appear smaller than wild-type with observation of more atrophic tubules completely devoid of spermatogonia and mature sperm
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immune system
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• occasional inflammation is observed in the forestomach
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• occasional inflammation is observed in the tongue
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homeostasis/metabolism
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• severe edema as well as atypical cells are observed in the forestomach and tongue
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digestive/alimentary system
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• in morbid animals (treated with gancyclovir), loss of Sox2-positive layers closest to the basal layer is observed in the forestomach while the stratified layers remain intact
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• necropsy of animals treated with gancyclovir for 13 days shows ulcers of the stomach and oral mucoa; these likely result in the observed morbidity and death
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• occasional inflammation is observed in the forestomach
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endocrine/exocrine glands
small testis
(
J:177655
)
|
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• 3 months following end of a 1-week gancyclovir treatment of 3- or 7-week old mice, testes appear smaller than wild-type with observation of more atrophic tubules completely devoid of spermatogonia and mature sperm
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