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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k10tm1Dsd
targeted mutation 1, Donna S Dorow
MGI:5296039
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Map3k10tm1Dsd/Map3k10tm1Dsd
Map3k11tm1Rjd/Map3k11tm1Rjd 		involves: 129 * 129S6/SvEvTac * C57BL/6J MGI:5296041
cx2
 		Map3k10tm1Dsd/Map3k10tm1Dsd
Map3k11tm2.1Rjd/Map3k11tm2.1Rjd 		involves: 129 * C57BL/6J MGI:5296040


Genotype
MGI:5296041
cx1
Allelic
Composition		 Map3k10tm1Dsd/Map3k10tm1Dsd
Map3k11tm1Rjd/Map3k11tm1Rjd
Genetic
Background		 involves: 129 * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k10tm1Dsd mutation (0 available); any Map3k10 mutation (34 available)
Map3k11tm1Rjd mutation (0 available); any Map3k11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal circulating cytokine level ( J:177426 )
• suppression of LPS induced inflammatory cytokine production
abnormal circulating chemokine level ( J:177426 )
• suppression of LPS induced inflammatory chemokine production
abnormal response to infection ( J:177426 )
• suppression of LPS induced inflammatory cytokine and chemokine production

homeostasis/metabolism
abnormal circulating cytokine level ( J:177426 )
• suppression of LPS induced inflammatory cytokine production
abnormal circulating chemokine level ( J:177426 )
• suppression of LPS induced inflammatory chemokine production




Genotype
MGI:5296040
cx2
Allelic
Composition		 Map3k10tm1Dsd/Map3k10tm1Dsd
Map3k11tm2.1Rjd/Map3k11tm2.1Rjd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k10tm1Dsd mutation (0 available); any Map3k10 mutation (34 available)
Map3k11tm2.1Rjd mutation (0 available); any Map3k11 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal circulating cytokine level ( J:177426 )
• suppression of LPS induced inflammatory cytokine production
abnormal circulating chemokine level ( J:177426 )
• suppression of LPS induced inflammatory chemokine production
abnormal response to infection ( J:177426 )
• suppression of LPS induced inflammatory cytokine and chemokine production

homeostasis/metabolism
abnormal circulating cytokine level ( J:177426 )
• suppression of LPS induced inflammatory cytokine production
abnormal circulating chemokine level ( J:177426 )
• suppression of LPS induced inflammatory chemokine production




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory