Analysis Tools
mortality/aging
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• by 6 months of age, exacerbated in female mice during pregnancy
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immune system
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• mice exhibit normal stimulated T cell proliferation and cytokine production
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• when stimulated by TLR4 agonist LPS, the TLR2/6 agonist lipoteichoic acid (LTA), the TLR7 agonist R848, or anti-IgM and anti-CD40 antibodies
• however, proliferation in response to the TLR9 ligand ODN1826 is normal
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• severe autoimmunity is exacerbated in female mice during pregnancy
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• at 2 to 3 months of age
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• 4 to 5 times at 4 months of age
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• in the spleen and lymph node
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• in the spleen and lymph node
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• in the spleen and lymph node
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• in the Peyer's Patch, peribronchial lymphoid tissue, hepatic portal tracts
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• 4 to 5 times in the blood
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• in the Peyer's Patch, peribronchial lymphoid tissue, hepatic portal tracts
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• mice exhibit an increase in the proportion of activated effector T cells and a decrease in the proportion of naive cells in the spleen and lymph nodes compared with wild-type mice
• however, the proportion of CD4+ and CD8+ T cells is normal in the spleen
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• mice exhibit an increase in the proportion of activated effector T cells and a decrease in the proportion of naive cells in the spleen and lymph nodes compared with wild-type mice
• however, the proportion of CD4+ and CD8+ T cells is normal in the spleen
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• without loss of spleen architecture
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• splenic germinal center formation is increased compared to in wild-type mice
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• without loss of spleen architecture
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• Peyer's patches exhibit plasma cells and neutrophils
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• mice exhibit immune complex deposition (C3, C1q, and IgG) in the kidney unlike wild-type mice
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• from B cells stimulated with LPS alone or with anti-CD40 antibodies
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• from B cells stimulated with LPS alone or with anti-CD40 antibodies or TLR stimulated bone marrow-derived dendritic cells
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• from TLR stimulated bone marrow-derived dendritic cells
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• after 16 and 20 weeks
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• at 20 to 24 weeks, mice develop severe renal disease (severe generalized global membranoproliferative glomerulonephritis with infiltration of neutrophils and plasma cells and thickening of glomerular capillary loops and Bowman's capsule basement membrane regions)
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cardiovascular system
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• mice develop vascular lesions in arterioles of the spleen and heart and occasionally Peyer's Patch arterioles and peripancreatic arteries
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• with severe inflammatory cell infiltrate
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cellular
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• in TNF-treated mouse embryonic fibroblasts
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• when stimulated by TLR4 agonist LPS, the TLR2/6 agonist lipoteichoic acid (LTA), the TLR7 agonist R848, or anti-IgM and anti-CD40 antibodies
• however, proliferation in response to the TLR9 ligand ODN1826 is normal
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digestive/alimentary system
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• intestinal nodules
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endocrine/exocrine glands
liver/biliary system
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• mice exhibit hepatic portal tract lesions with increased numbers of hematopoietic cells, lymphocytes, plasma cells, macrophages, neutrophils, bridging fibrosis and biliary hyperplasia
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renal/urinary system
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• at 20 to 24 weeks, mice develop severe renal disease (severe generalized global membranoproliferative glomerulonephritis with infiltration of neutrophils and plasma cells and thickening of glomerular capillary loops and Bowman's capsule basement membrane regions)
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hematopoietic system
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• when stimulated by TLR4 agonist LPS, the TLR2/6 agonist lipoteichoic acid (LTA), the TLR7 agonist R848, or anti-IgM and anti-CD40 antibodies
• however, proliferation in response to the TLR9 ligand ODN1826 is normal
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• at 2 to 3 months of age
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• 4 to 5 times at 4 months of age
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• in the spleen and lymph node
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• in the spleen and lymph node
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• in the spleen and lymph node
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• in the Peyer's Patch, peribronchial lymphoid tissue, hepatic portal tracts
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• 4 to 5 times in the blood
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• in the Peyer's Patch, peribronchial lymphoid tissue, hepatic portal tracts
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• mice exhibit an increase in the proportion of activated effector T cells and a decrease in the proportion of naive cells in the spleen and lymph nodes compared with wild-type mice
• however, the proportion of CD4+ and CD8+ T cells is normal in the spleen
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• mice exhibit an increase in the proportion of activated effector T cells and a decrease in the proportion of naive cells in the spleen and lymph nodes compared with wild-type mice
• however, the proportion of CD4+ and CD8+ T cells is normal in the spleen
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• without loss of spleen architecture
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• splenic germinal center formation is increased compared to in wild-type mice
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• without loss of spleen architecture
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growth/size/body
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• at 2 to 3 months of age
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• 4 to 5 times at 4 months of age
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