Phenotypes associated with this allele

• Allele Symbol: Pnpla2^tm1.1Hsul
• Allele Name: targeted mutation 1.1, Hei Sul
• Allele ID: MGI:5296237
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pnpla2^tm1.1Hsul/Pnpla2^tm1.1Hsul Tg(Fabp4-cre)1Rev/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:5296241

Genotype
MGI:5296241

cn1

• Allelic Composition: Pnpla2^tm1.1Hsul/Pnpla2^tm1.1Hsul; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:176083 )

• pale color

increased brown adipose tissue amount ( J:176083 )

• 4.9-fold

increased brown fat cell size ( J:176083 )

increased white fat cell size ( J:176083 )

increased gonadal fat pad weight ( J:176083 )

• 1.4-fold after 20 weeks on a high fat diet

increased inguinal fat pad weight ( J:176083 )

• 2.0-fold after 20 weeks on a high fat diet

increased renal fat pad weight ( J:176083 )

• 1.9-fold after 20 weeks on a high fat diet

increased total fat pad weight ( J:176083 )

• when fed standard chow

abnormal adipose tissue physiology ( J:176083 )

• under basal and isoproterenol-stimulated conditions, glycerol release and fatty acid release are decreased compared to in wild-type cells

• turnover of triacylglyceride and de novo palmitate is decreased in brown and white adipose tissue compared to in wild-type mice

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice

decreased adipocyte glucose uptake ( J:176083 )

• impaired glucose uptake in brown and white adipose tissue

homeostasis/metabolism

decreased fatty acid oxidation ( J:176083 )

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice

increased susceptibility to diet-induced obesity ( J:176083 )

• at 12 and 14 weeks when fed a high fat diet

impaired adaptive thermogenesis ( J:176083 )

• in a fasted state with decreased triacylglyceride hydrolase activity

decreased circulating glucose level ( J:176083 )

decreased circulating insulin level ( J:176083 )

abnormal oxygen consumption ( J:176083 )

• in response to the beta3-agonist CL316243, mice fail to exhibit an increase in oxygen consumption unlike similarly treated wild-type mice

decreased oxygen consumption ( J:176083 )

• in fasted mice under cold exposure

increased insulin sensitivity ( J:176083 )

• in the liver with lower diacylglyceride levels

impaired lipolysis ( J:176083 )

• 60% in brown adipose tissue under basal conditions

growth/size/body

increased susceptibility to weight gain ( J:176083 )

• when fed standard chow

increased susceptibility to diet-induced obesity ( J:176083 )

• at 12 and 14 weeks when fed a high fat diet

cellular

decreased adipocyte glucose uptake ( J:176083 )

• impaired glucose uptake in brown and white adipose tissue

decreased fatty acid oxidation ( J:176083 )

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice