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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata5tm1.1Nemr
targeted mutation 1.1, Mona Nemer
MGI:5296251
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gata5tm1.1Nemr/Gata5tm1.1Nemr
Tg(Tek-cre)1Ywa/0 		involves: 129 * C57BL/6 * SJL MGI:5296321
cn2
 		Gata5tm1.1Nemr/Gata5tm1.1Nemr
Tg(Tagln-cre)1Her/0 		involves: C57BL/6 * SJL MGI:5707856


Genotype
MGI:5296321
cn1
Allelic
Composition		 Gata5tm1.1Nemr/Gata5tm1.1Nemr
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata5tm1.1Nemr mutation (0 available); any Gata5 mutation (17 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Bicuspid aortic valve in Gata5tm1.2Nemr/Gata5tm1.2Nemr Tg(Tek-cre)1Ywa/0 mice

cardiovascular system
abnormal aortic valve cusp morphology ( J:175663 )
• mice exhibit the fusion of the right-coronary and noncoronary valve leaflets unlike in control mice
bicuspid aortic valve ( J:175663 )
• in 3 of 14 mice compared with 1 of 31 control mice




Genotype
MGI:5707856
cn2
Allelic
Composition		 Gata5tm1.1Nemr/Gata5tm1.1Nemr
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata5tm1.1Nemr mutation (0 available); any Gata5 mutation (17 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:227997 )
N
• mice exhibit normal blood pressure and vasodilatory response to acetylcholine




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory