mortality/aging
• fewer than expected mice are produced
|
• many mice die at weaning coinciding with the transition from milk to solid diet
• however, delaying weaning to 6 weeks with gruel-feeding of age decreases lethality
|
digestive/alimentary system
• small hemorrhages throughout the duodenum, jejunum, and ileum in mice that die shortly after weaning
|
• mice that survive to adulthood exhibit hyperproliferation of epithelial cells throughout the small intestine and cecum with accumulation of mucus in crypt cells compared with wild-type mice
|
• mice that survive to adulthood exhibit multifocal accumulation of amorphous, eosiniphilic material between acinar cells unlike in wild-type mice
|
• bowel wall thickening in mice that survive to adulthood
• intestinal perforation in one of the mice that die shortly after weaning
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• in mice that die shortly after weaning
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• in some mice that die shortly after weaning
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homeostasis/metabolism
• mice that survive to adulthood exhibit blunted blood glucose response to the stress of anesthesia compared with wild-type mice
|
hypoglycemia
(
J:177616
)
• in mice that survive to adulthood
|
• in mice that survive to adulthood
|
• in mice that survive to adulthood
|
growth/size/body
• in mice that survive to adulthood
|
• severe neonatal growth failure
|
endocrine/exocrine glands
• mice that survive to adulthood exhibit multifocal accumulation of amorphous, eosiniphilic material between acinar cells unlike in wild-type mice
|
• disorganized alpha, beta, and delta cell islets in mice that survive to adulthood
• however, the ratio of islet volume to pancreatic volume is normal
|
cardiovascular system
• small hemorrhages throughout the duodenum, jejunum, and ileum in mice that die shortly after weaning
|
cellular
• mice that survive to adulthood exhibit hyperproliferation of epithelial cells throughout the small intestine and cecum with accumulation of mucus in crypt cells compared with wild-type mice
|