Phenotypes associated with this allele

• Allele Symbol: Vipr1^tm1Msod
• Allele Name: targeted mutation 1, Mary Sue O'Dorisio
• Allele ID: MGI:5296326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vipr1^tm1Msod/Vipr1^tm1Msod	B6.129-Vipr1^tm1Msod	MGI:5296327

Genotype
MGI:5296327

hm1

• Allelic Composition: Vipr1^tm1Msod/Vipr1^tm1Msod
• Genetic Background: B6.129-Vipr1^tm1Msod

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality at weaning, incomplete penetrance ( J:177616 )

• fewer than expected mice are produced

preweaning lethality, incomplete penetrance ( J:177616 )

• many mice die at weaning coinciding with the transition from milk to solid diet

• however, delaying weaning to 6 weeks with gruel-feeding of age decreases lethality

digestive/alimentary system

small intestine hemorrhage ( J:177616 )

• small hemorrhages throughout the duodenum, jejunum, and ileum in mice that die shortly after weaning

abnormal enterocyte proliferation ( J:177616 )

• mice that survive to adulthood exhibit hyperproliferation of epithelial cells throughout the small intestine and cecum with accumulation of mucus in crypt cells compared with wild-type mice

abnormal exocrine pancreas morphology ( J:177616 )

• mice that survive to adulthood exhibit multifocal accumulation of amorphous, eosiniphilic material between acinar cells unlike in wild-type mice

abnormal intestine morphology ( J:177616 )

• intestinal perforation in one of the mice that die shortly after weaning

• bowel wall thickening in mice that survive to adulthood

enlarged cecum ( J:177616 )

• in mice that die shortly after weaning

intestinal obstruction ( J:177616 )

• in some mice that die shortly after weaning

homeostasis/metabolism

abnormal glucose homeostasis ( J:177616 )

• mice that survive to adulthood exhibit blunted blood glucose response to the stress of anesthesia compared with wild-type mice

hypoglycemia ( J:177616 )

• in mice that survive to adulthood

impaired glucose tolerance ( J:177616 )

• in mice that survive to adulthood

increased insulin sensitivity ( J:177616 )

• in mice that survive to adulthood

growth/size/body

decreased body weight ( J:177616 )

• in mice that survive to adulthood

postnatal growth retardation ( J:177616 )

• severe neonatal growth failure

endocrine/exocrine glands

abnormal exocrine pancreas morphology ( J:177616 )

• mice that survive to adulthood exhibit multifocal accumulation of amorphous, eosiniphilic material between acinar cells unlike in wild-type mice

disorganized pancreatic islets ( J:177616 )

• disorganized alpha, beta, and delta cell islets in mice that survive to adulthood

• however, the ratio of islet volume to pancreatic volume is normal

cardiovascular system

small intestine hemorrhage ( J:177616 )

• small hemorrhages throughout the duodenum, jejunum, and ileum in mice that die shortly after weaning

cellular

abnormal enterocyte proliferation ( J:177616 )

• mice that survive to adulthood exhibit hyperproliferation of epithelial cells throughout the small intestine and cecum with accumulation of mucus in crypt cells compared with wild-type mice