Phenotypes associated with this allele

• Allele Symbol: Nfkbib^tm1.2Rsch
• Allele Name: targeted mutation 1.2, Roland Schmid
• Allele ID: MGI:5296337
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbib^tm1.2Rsch/Nfkbib^tm1.2Rsch	B6.129P2-Nfkbib^tm1.2Rsch	MGI:5296352

Genotype
MGI:5296352

hm1

• Allelic Composition: Nfkbib^tm1.2Rsch/Nfkbib^tm1.2Rsch
• Genetic Background: B6.129P2-Nfkbib^tm1.2Rsch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:176877 )

• resistant to lethal effects of lipopolysaccharide (LPS)

• initial signs of LPS shock but often complete recovery by 72 hours

immune system

abnormal immune system morphology ( J:176877 )

increased marginal zone B cell number ( J:176877 )

decreased B cell number ( J:176877 )

• reduced numbers of naive B cells

increased memory T cell number ( J:176877 )

• in the spleen

increased macrophage cell number ( J:176877 )

• increased bone marrow derived macrophage

abnormal immune system physiology ( J:176877 )

abnormal cytokine secretion ( J:176877 )

abnormal interleukin-1 beta secretion ( J:176877 )

• production in response to LPS is particularly impaired relative to controls

• liver levels of mRNA are reduced relative to controls

abnormal interleukin-6 secretion ( J:176877 )

• levels are only modestly increased by LPS exposure as compared to controls

• liver levels of mRNA are lower relative to controls

abnormal tumor necrosis factor secretion ( J:176877 )

• levels are only modestly increased by LPS exposure as compared to controls

• liver levels of mRNA are lower relative to controls

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:176877 )

• resistant to lethal effects of lipopolysaccharide (LPS)

• initial signs of LPS shock but often complete recovery by 72 hours

hematopoietic system

increased marginal zone B cell number ( J:176877 )

decreased B cell number ( J:176877 )

• reduced numbers of naive B cells

increased memory T cell number ( J:176877 )

• in the spleen

increased macrophage cell number ( J:176877 )

• increased bone marrow derived macrophage