Phenotypes associated with this allele

• Allele Symbol: Brd1^tm1Hko
• Allele Name: targeted mutation 1, Haruhiko Koseki
• Allele ID: MGI:5296490
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd1^tm1Hko/Brd1^tm1Hko	B6.129-Brd1^tm1Hko	MGI:5296499

Genotype
MGI:5296499

hm1

• Allelic Composition: Brd1^tm1Hko/Brd1^tm1Hko
• Genetic Background: B6.129-Brd1^tm1Hko

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:177092 )

• all mice die between E12.5 and E16.5

embryonic lethality during organogenesis, incomplete penetrance ( J:177092 )

• some mice die between E12.5 and E14.5

embryo

embryonic growth retardation ( J:177092 )

• in 92 of 99 mice at E12.5

open neural tube ( J:177092 )

• in 30 of 135 mice between E8.5 and E12.5

abnormal embryonic hematopoiesis ( J:177092 )

• the number of yolk sac cells and Ter119+ erythroblasts in the yolk sac are increased compared with wild-type mice

abnormal embryonic erythropoiesis ( J:177092 )

• at E12.5, erythopoeisis remain active unlike in wild-type mice

hematopoietic system

abnormal embryonic hematopoiesis ( J:177092 )

• the number of yolk sac cells and Ter119+ erythroblasts in the yolk sac are increased compared with wild-type mice

abnormal embryonic erythropoiesis ( J:177092 )

• at E12.5, erythopoeisis remain active unlike in wild-type mice

abnormal erythropoiesis ( J:177092 )

anemia ( J:177092 )

• pale embryos at E12.5

impaired hematopoiesis ( J:177092 )

• impaired in the fetal liver

decreased erythroid progenitor cell number ( J:177092 )

• in the fetal liver

decreased erythroblast number ( J:177092 )

• beyond the pro-erythroblast stage in fetal liver

abnormal fetal liver hematopoietic progenitor cell morphology ( J:177092 )

• at E12.5, mice exhibit a 2-fold reduction in Ter119+ erythroid cells compared with wild-type mice

vision/eye

abnormal lens morphology ( J:177092 )

• in 74 of 122 embryos at E10.5-E12.5

abnormal optic cup morphology ( J:177092 )

• disoriented in 74 of 122 embryos at E10.5-E12.5

growth/size/body

embryonic growth retardation ( J:177092 )

• in 92 of 99 mice at E12.5

cellular

increased apoptosis ( J:177092 )

• of fetal liver erythroblasts

liver/biliary system

decreased hepatoblast number ( J:177092 )

• the number of Dlk1+ hepatoblasts is reduced compared to in wild-type mice

• however, differentiation of hepatocytes and cholangiocytes is normal

small liver ( J:177092 )

• small fetal liver

nervous system

open neural tube ( J:177092 )

• in 30 of 135 mice between E8.5 and E12.5

integument

pallor ( J:177092 )

• pale embryos at E12.5