Phenotypes associated with this allele

• Allele Symbol: Fn1^tm2.1Ref
• Allele Name: targeted mutation 2.1, Reinhard Fassler
• Allele ID: MGI:5296500
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn1^tm2.1Ref/Fn1^tm2.1Ref	involves: 129S1/Sv * 129X1/SvJ	MGI:5296503

Genotype
MGI:5296503

hm1

• Allelic Composition: Fn1^tm2.1Ref/Fn1^tm2.1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:177821 )

• no homozygous mice identified after birth

• normal Mendelian distribution to E10.5

• no homozygotes with beating hearts recoverable after E10.5

• disintegration and resorption occurring by E11.5

embryo

abnormal vitelline vasculature morphology ( J:177821 )

• vitelline and embryonic vasculature dilated and sometimes ruptured at E9.5

increased tail bud apoptosis ( J:177821 )

• apoptotic death of tail bud derived mesoderm

incomplete embryo turning ( J:177821 )

• incomplete at E9.5

short rostral-caudal axis ( J:177821 )

• slightly shortened anterior-posterior axis at E8.5

abnormal embryonic tissue morphology ( J:177821 )

abnormal rostral-caudal patterning of the somites ( J:177821 )

• posterior trunk lacking somites at E9.5

absent limb buds ( J:177821 )

• at E9.5

• forelimb buds develop at E10.5

kinked neural tube ( J:177821 )

• at E.5

incomplete somite formation ( J:177821 )

• never more than 12-13 somite pairs

• shortened posterior trunk lacking somites at E9.5

limbs/digits/tail

absent limb buds ( J:177821 )

• at E9.5

• forelimb buds develop at E10.5

kinked tail ( J:177821 )

• at E9.5

cardiovascular system

cardiovascular system phenotype ( J:177821 )

N • heart present at E10.5

abnormal vitelline vasculature morphology ( J:177821 )

• vitelline and embryonic vasculature dilated and sometimes ruptured at E9.5

nervous system

kinked neural tube ( J:177821 )

• at E.5

craniofacial

craniofacial phenotype ( J:177821 )

N • head structures are normally developed at E10.5

cellular

increased tail bud apoptosis ( J:177821 )

• apoptotic death of tail bud derived mesoderm