All Phenotypes Glis3<tm1.2Chan> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Glis3^tm1.2Chan/Glis3^tm1.2Chan	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:5296615
ht2	Glis3^tm1.2Chan/Glis3⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J	MGI:5296616

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:177082 )

• mice died between P4 and P6

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:177082 )

N	• exocrine pancreas is normal

decreased pancreatic alpha cell number ( J:177082 )

• at E15.5, E17.5, and neonates

absent pancreatic alpha cells ( J:177082 )

• at E12.5

decreased pancreatic beta cell number ( J:177082 )

• at E15.5, E17.5, and neonates

absent pancreatic beta cells ( J:177082 )

• at E12.5

decreased pancreatic delta cell number ( J:177082 )

• at E17.5 and neonates

decreased pancreatic epsilon cell number ( J:177082 )

• at E17.5 and neonates

small pancreatic islets ( J:177082 )

• in neonates

disorganized pancreatic islets ( J:177082 )

• in neonates

decreased insulin secretion ( J:177082 )

• in the pancreas

homeostasis/metabolism

decreased insulin secretion ( J:177082 )

• in the pancreas

increased circulating glucose level ( J:177082 )

• mild at birth

hyperglycemia ( J:177082 )

• by P4

decreased circulating insulin level ( J:177082 )

• at P4

increased circulating ketone body level ( J:177082 )

• severe at P4

dehydration ( J:177082 )

• at P4

growth/size/body

decreased body size ( J:177082 )

• at P4

postnatal growth retardation ( J:177082 )

• growth arrest at P1

Allelic Composition	Glis3^tm1.2Chan/Glis3⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glis3^tm1.2Chan mutation (0 available); any Glis3 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:177082 )

• in the pancreas

homeostasis/metabolism

decreased insulin secretion ( J:177082 )

• in the pancreas

decreased circulating insulin level ( J:177082 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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