Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cttntm1.2Dvst targeted mutation 1.2, Dietmar Vestweber MGI:5296621 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: fewer than expected mice are produced from mating heterozygotes unlike mice on a mixed background
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| N |
• Background Sensitivity: male female ratio is normal unlike mice on a mixed background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
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• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
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• reduced neutrophils adhesion to endothelium
|
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, constitutively active RhoG restores neutrophil transmigration
|
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• decrease diameter and increased wall shear rate
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• more than 2-fold in skin vasculature
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• murine lung endothelial cells exhibit reduced contact integrity and increased higher permeability compared with wild-type cells
• however, lung endothelial cell permeability is restored by treatment with 007
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• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
|
|
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
|
|
• reduced neutrophils adhesion to endothelium
|
|
• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
|
|
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, neutrophil adhesion is normal and constitutively active RhoG restores neutrophil transmigration
|
|
• reduced neutrophils adhesion to endothelium
|
|
• increased rolling velocity and rolling flux fraction with reduced neutrophils adhered to endothelium
• neutrophil extravasation through a monolayer of primary murine lung endothelial cells is reduced compared with wild-type cells
• however, constitutively active RhoG restores neutrophil transmigration
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: mice are produced at expected ratios unlike mice on a congenic C57BL/6 background
|
|
• Background Sensitivity: preference towards female offspring unlike mice on a congenic C57BL/6 background
|
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: fewer than expected mice are produced from mating heterozygotes unlike mice on a mixed background
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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