All Phenotypes Aire<tm1.1(cre)Ghr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aire^{tm1.1(cre)Ghr}
targeted mutation 1.1, Georg A Hollander
MGI:5296650

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aire^{tm1.1(cre)Ghr}/Aire^{tm1.1(cre)Ghr}	Not Specified	MGI:5296658

Allelic Composition	Aire^{tm1.1(cre)Ghr}/Aire^{tm1.1(cre)Ghr}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aire^{tm1.1(cre)Ghr} mutation (0 available); any Aire mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased dendritic cell number ( J:176844 )

• reduced density of thymic dendritic cells in the middle medullary region of the thymus

increased dendritic cell number ( J:176844 )

• increased density in deep cortical regions of the thymus

decreased regulatory T cell number ( J:176844 )

• reduced numbers of natural T reg cells in the thymus

hematopoietic system