About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Men1tm2.1Mmey
targeted mutation 2.1, Matthew Meyerson
MGI:5296656
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5296659
cn2
 		Kdm5atm1Kael/Kdm5atm1Kael
Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5296660


Genotype
MGI:5296659
cn1
Allelic
Composition		 Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Men1tm2.1Mmey mutation (0 available); any Men1 mutation (40 available)
Tg(Ins2-cre)23Herr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175625 )
• median survival is 45 weeks

endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:175625 )
• in 5 of 10 mice at 2 months of age
• in 4 of 9 mice at 4 months of age
pancreatic islet hyperplasia ( J:175625 )
• in 5 of 10 mice at 2 months of age
• in 4 of 9 mice at 4 months of age
increased insulinoma incidence ( J:175625 )
• in 3 of 16 mice at 8 months of age
• in all mice at 10 months of age
abnormal pancreas physiology ( J:175625 )
• islet proliferation is increased compared to in control mice

neoplasm
increased insulinoma incidence ( J:175625 )
• in 3 of 16 mice at 8 months of age
• in all mice at 10 months of age




Genotype
MGI:5296660
cn2
Allelic
Composition		 Kdm5atm1Kael/Kdm5atm1Kael
Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5atm1Kael mutation (1 available); any Kdm5a mutation (76 available)
Men1tm2.1Mmey mutation (0 available); any Men1 mutation (40 available)
Tg(Ins2-cre)23Herr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175625 )
• median survival is 69 weeks

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:175625 )
N
• islet proliferation is normal
abnormal pancreatic islet morphology ( J:175625 )
• atypia in 2 of 16 mice at 8 months of age
pancreatic islet hyperplasia ( J:175625 )
• in 1 of 8 mice at 2 months of age
• in 3 of 16 mice at 8 months of age
increased insulinoma incidence ( J:175625 )
• in 2 of 21 mice at 10 months of age

neoplasm
increased insulinoma incidence ( J:175625 )
• in 2 of 21 mice at 10 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory