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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh3kbp1tm1Kuro
targeted mutation 1, Tomohiro Kurosaki
MGI:5296768
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 * NZB MGI:5296787
cn2
 		Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/? 		involves: BALB/c * C57BL/6 * NZB MGI:5296788


Genotype
MGI:5296787
cn1
Allelic
Composition		 Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176805 )
N
• no gross development arrest in bone marrow
decreased B cell number ( J:176805 )
• recirculating B cells reduced about 20%
decreased immature B cell number ( J:176805 )
• reduced about 20%
decreased transitional stage T2 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased transitional stage T3 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased B-1a cell number ( J:176805 )
• peritoneal B-1a B cells are reduced about 8 fold
decreased follicular B cell number ( J:176805 )
• reduced about 20% in the spleen
abnormal B cell physiology ( J:176805 )
• antigen specific B cells fail to increase due to T cell independent type II antibody response
• B cell proliferation after anti-IgM stimulation is severely reduced
abnormal humoral immune response ( J:176805 )
• T cell independent type II antibody responses are considerably reduced

hematopoietic system
decreased B cell number ( J:176805 )
• recirculating B cells reduced about 20%
decreased immature B cell number ( J:176805 )
• reduced about 20%
decreased transitional stage T2 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased transitional stage T3 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased B-1a cell number ( J:176805 )
• peritoneal B-1a B cells are reduced about 8 fold
decreased follicular B cell number ( J:176805 )
• reduced about 20% in the spleen
abnormal B cell physiology ( J:176805 )
• antigen specific B cells fail to increase due to T cell independent type II antibody response
• B cell proliferation after anti-IgM stimulation is severely reduced




Genotype
MGI:5296788
cn2
Allelic
Composition		 Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (2 available); any Gt(ROSA)26Sor mutation (968 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176805 )
N
• T cell independent type II antibody responses are restored
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective

hematopoietic system
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory