About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh3kbp1tm1Kuro
targeted mutation 1, Tomohiro Kurosaki
MGI:5296768
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 * NZB MGI:5296787
cn2
 		Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/? 		involves: BALB/c * C57BL/6 * NZB MGI:5296788


Genotype
MGI:5296787
cn1
Allelic
Composition		 Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176805 )
N
• no gross development arrest in bone marrow
decreased B cell number ( J:176805 )
• recirculating B cells reduced about 20%
decreased immature B cell number ( J:176805 )
• reduced about 20%
decreased transitional stage T2 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased transitional stage T3 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased B-1a cell number ( J:176805 )
• peritoneal B-1a B cells are reduced about 8 fold
decreased follicular B cell number ( J:176805 )
• reduced about 20% in the spleen
abnormal B cell physiology ( J:176805 )
• antigen specific B cells fail to increase due to T cell independent type II antibody response
• B cell proliferation after anti-IgM stimulation is severely reduced
abnormal humoral immune response ( J:176805 )
• T cell independent type II antibody responses are considerably reduced

hematopoietic system
decreased B cell number ( J:176805 )
• recirculating B cells reduced about 20%
decreased immature B cell number ( J:176805 )
• reduced about 20%
decreased transitional stage T2 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased transitional stage T3 B cell number ( J:176805 )
• reduced about 20% in the spleen
decreased B-1a cell number ( J:176805 )
• peritoneal B-1a B cells are reduced about 8 fold
decreased follicular B cell number ( J:176805 )
• reduced about 20% in the spleen
abnormal B cell physiology ( J:176805 )
• antigen specific B cells fail to increase due to T cell independent type II antibody response
• B cell proliferation after anti-IgM stimulation is severely reduced




Genotype
MGI:5296788
cn2
Allelic
Composition		 Sh3kbp1tm1Kuro/Sh3kbp1tm1Kuro
Cd79atm1(cre)Reth/Cd79a+
Gt(ROSA)26Sortm4(Ikbkb)Rsky/?
Genetic
Background		 involves: BALB/c * C57BL/6 * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm4(Ikbkb)Rsky mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Sh3kbp1tm1Kuro mutation (0 available); any Sh3kbp1 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:176805 )
N
• T cell independent type II antibody responses are restored
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective

hematopoietic system
decreased B-1a cell number ( J:176805 )
• B-1a cell development continues to be defective




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory