Allele Symbol Allele Name Allele ID |
Gucy1b1tm1Zhen targeted mutation 1, Zhenyu Li MGI:5296786 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• NO-induced cGMP production is abolished in platelets compared to in control cells
• agonist-induced cGMP production is reduced in platelets compared to in control cells
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• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells
• however, high concentrations of agonists induce normal aggregation
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• time to form FeCl3-induced carotid artery thrombosis is prolonged compared to in control mice
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N |
• mice exhibit normal blood pressure
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N |
• mice exhibit normal blood counts, including platelets
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• NO-induced cGMP production is abolished in platelets compared to in control cells
• agonist-induced cGMP production is reduced in platelets compared to in control cells
|
• collagen- or thrombin-induced platelet secretion and aggregation are attenuated unlike in control cells
• however, high concentrations of agonists induce normal aggregation
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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