All Phenotypes Crb2<tm1Vlcg> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:177837 )

• completely resorbed by E12.5

abnormal vitelline vasculature morphology ( J:177837 )

• impaired yolk sac vasculogenesis

abnormal gastrulation ( J:177837 )

• severe malformations detected from the E7.75 late-gastrulation stage onward

failure of initiation of embryo turning ( J:177837 )

• do not start the turning process at E8 - E9

abnormal endoderm development ( J:177837 )

• embryonic endoderm appears expanded instead of being restricted only to the inner lining of the gut

abnormal mesoderm development ( J:177837 )

• the mesoderm germ layer is more compact and reduced in thickness

increased embryo size ( J:177837 )

• at E10.5

abnormal embryonic tissue morphology ( J:177837 )

• lack distinguishable embryonic structures at E10.5

abnormal embryonic epiblast morphology ( J:177837 )

• the apicobasal polarity of the epiblast is disturbed leading to impaired epithelial to mesenchymal transition at gastrulation

abnormal head fold morphology ( J:177837 )

• formation of the head fold is severely disturbed at E7.75

abnormal embryonic neuroepithelium morphology ( J:177837 )

• poorly developed

• discontinuous at E8.25

• partially disassembled, lacks sheet like structure and mixes with the mesoderm at E9.5

open neural tube ( J:177837 )

• closure does not occur

abnormal notochord morphology ( J:177837 )

• notochord is discontinuous since E7.75, suggesting a defect in notochord formation

abnormal primitive streak morphology ( J:177837 )

• wider than normal

• failure of epithelial to mesenchymal transition in the primitive streak

abnormal anterior primitive streak morphology ( J:177837 )

• after E7.5 the anterior end of the primitive streak has not shifted proximally, unlike in wild-type embryos

abnormal somite development ( J:177837 )

• development is disturbed at E7.75

• fail to develop well-segmented and patterned somites

• at E9.0 only have a few pre-somite pairs

small allantois ( J:177837 )

• fails to elongate

small amniotic cavity ( J:177837 )

• small

abnormal visceral yolk sac blood island morphology ( J:177837 )

• only some scattered clusters of blood islands are present at E10.5

abnormal chorioallantoic fusion ( J:177837 )

• the allantois fuses to the caudal yolk sac region

failure of chorioallantoic fusion ( J:177837 )

abnormal vitelline vasculature morphology ( J:177837 )

• impaired yolk sac vasculogenesis

absent heart tube ( J:177837 )

• absent

abnormal digestive system development ( J:177837 )

• at E8 lack the foregut and hindgut diverticulum

abnormal foregut morphology ( J:177837 )

• invagination is disturbed at E7.75