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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tfap4tm1.1Litt
targeted mutation 1.1, Dan R Littman
MGI:5296820
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tfap4tm1.1Litt/Tfap4tm1.1Litt involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5296823
cx2
 		Rr96tm2Litt/Rr96tm2Litt
Tfap4tm1.1Litt/Tfap4tm1.1Litt 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5296824


Genotype
MGI:5296823
hm1
Allelic
Composition		 Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap4tm1.1Litt mutation (0 available); any Tfap4 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:176461 )
• mice exhibit slightly lower than expected Mendelian frequency at birth

immune system
immune system phenotype ( J:176461 )
N
• the total number of thymocytes and frequencies of B and T cells in the spleen are normal
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in double negative thymocytes is impaired
• however, Cd4 silencing in Cd8+ mature thymocytes is normal

hematopoietic system
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in double negative thymocytes is impaired
• however, Cd4 silencing in Cd8+ mature thymocytes is normal




Genotype
MGI:5296824
cx2
Allelic
Composition		 Rr96tm2Litt/Rr96tm2Litt
Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Tfap4tm1.1Litt mutation (0 available); any Tfap4 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal

immune system
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory