Phenotypes associated with this allele

• Allele Symbol: Itgb1^tm11.1Ref
• Allele Name: targeted mutation 11.1, Reinhard Fassler
• Allele ID: MGI:5296846
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb1^tm11.1Ref/Itgb1^tm11.1Ref	involves: 129S1/Sv * 129X1/SvJ	MGI:5296859
cx2	Itgb1^tm11.1Ref/Itgb1^tm11.1Ref Tg(KRT5-SRC)CJdg/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5296894

Genotype
MGI:5296859

hm1

• Allelic Composition: Itgb1^tm11.1Ref/Itgb1^tm11.1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased keratinocyte adhesion ( J:176453 )

• keratinocytes exhibit decreased adhesion compared with single Y to F substitutions and wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:176453 )

• TPA-exposed mice exhibit fewer tumors than similarly treated wild-type mice

integument

integument phenotype ( J:177979 )

N • mice exhibit normal skin, hair bulbs, and wound healing

decreased keratinocyte adhesion ( J:176453 )

• keratinocytes exhibit decreased adhesion compared with single Y to F substitutions and wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:176453 )

• TPA-exposed mice exhibit fewer tumors than similarly treated wild-type mice

Genotype
MGI:5296894

cx2

• Allelic Composition: Itgb1^tm11.1Ref/Itgb1^tm11.1Ref; Tg(KRT5-SRC)CJdg/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

integument

integument phenotype ( J:176453 )

N • mice exhibit normal skin morphogenesis and homeostasis

neoplasm

neoplasm ( J:176453 )

N • TPA-treated mice exhibit the same increase in tumorigenesis as in similarly treated Tg(KRT5-SRC)CJdg mice