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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb1tm12.1Ref
targeted mutation 12.1, Reinhard Fassler
MGI:5296847
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb1tm12.1Ref/Itgb1tm12.1Ref involves: 129S1/Sv * 129X1/SvJ MGI:5296860
cn2
Itgb1tm1Ref/Itgb1tm12.1Ref
Tg(KRT5-cre)5132Jlj/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J MGI:5296861


Genotype
MGI:5296860
hm1
Allelic
Composition
Itgb1tm12.1Ref/Itgb1tm12.1Ref
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm12.1Ref mutation (0 available); any Itgb1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice died during embryonic development




Genotype
MGI:5296861
cn2
Allelic
Composition
Itgb1tm1Ref/Itgb1tm12.1Ref
Tg(KRT5-cre)5132Jlj/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm12.1Ref mutation (0 available); any Itgb1 mutation (60 available)
Itgb1tm1Ref mutation (0 available); any Itgb1 mutation (60 available)
Tg(KRT5-cre)5132Jlj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles

cellular
• keratinocytes exhibit impaired adhesion to a collagen/fibronectin coated plastic dishes compared with control cells (J:177979)
• keratinocytes do not adhere (J:203018)

integument
• keratinocytes exhibit impaired adhesion to a collagen/fibronectin coated plastic dishes compared with control cells (J:177979)
• keratinocytes do not adhere (J:203018)
• at P14, abnormally shaped hair follicles fail to grow as deeply into the subcutis compared to in control mice
• at 5 weeks, mice lose almost all their hair coat unlike controls
• at 14 days of age
• at 2 weeks, hair coat development is impaired compared with control mice
• hyperthickened with aberrant shaped cells at 14 days of age
• at the epidermal-dermal junction at 14 days of age
• at 5 weeks due to mechanical stress
• at 2 weeks, skin pigmentation is impaired compared with control mice

pigmentation
• at 2 weeks, skin pigmentation is impaired compared with control mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory