About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sgcetm1Vinni
targeted mutation 1, Vincenzo Nigro
MGI:5296936
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sgcetm1Vinni/Sgcetm1Vinni B6.129P2-Sgcetm1Vinni MGI:5296943
cx2
 		Sgcatm1Kcam/Sgcatm1Kcam
Sgcetm1Vinni/Sgcetm1Vinni 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5296946


Genotype
MGI:5296943
hm1
Allelic
Composition		 Sgcetm1Vinni/Sgcetm1Vinni
Genetic
Background		 B6.129P2-Sgcetm1Vinni
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcetm1Vinni mutation (1 available); any Sgce mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:177563 )
N
• mice exhibit normal heart morphology




Genotype
MGI:5296946
cx2
Allelic
Composition		 Sgcatm1Kcam/Sgcatm1Kcam
Sgcetm1Vinni/Sgcetm1Vinni
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgcatm1Kcam mutation (4 available); any Sgca mutation (26 available)
Sgcetm1Vinni mutation (1 available); any Sgce mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac muscle necrosis ( J:177563 )
• at 2 months of age
• severe at 1 year of age
abnormal heart left ventricle morphology ( J:177563 )
• mice exhibit increased left ventricular end diastolic diameter and left ventricular end systolic diameter compared with wild-type mice
cardiac fibrosis ( J:177563 )
• at 6 months of age
• severe at 1 year of age
decreased cardiac muscle contractility ( J:177563 )
• reduced fractional shortening and ejection fraction
cardiomyopathy ( J:177563 )
• at 2 months of age with large areas of necrotic areas, inflammatory infiltration, and centralized nuclei
• exercise worsens cardiac pathology

immune system

muscle
muscle phenotype ( J:177563 )
N
• mice exhibit normal diaphragm morphology
cardiac muscle necrosis ( J:177563 )
• at 2 months of age
• severe at 1 year of age
decreased cardiac muscle contractility ( J:177563 )
• reduced fractional shortening and ejection fraction
cardiomyopathy ( J:177563 )
• at 2 months of age with large areas of necrotic areas, inflammatory infiltration, and centralized nuclei
• exercise worsens cardiac pathology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory