Phenotypes associated with this allele

• Allele Symbol: Bhmt^tm1.2Zei
• Allele Name: targeted mutation 1.2, Steven Zeisel
• Allele ID: MGI:5297083
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bhmt^tm1.2Zei/Bhmt^tm1.2Zei	involves: 129P2/OlaHsd * C57BL/6	MGI:5297110

Genotype
MGI:5297110

hm1

• Allelic Composition: Bhmt^tm1.2Zei/Bhmt^tm1.2Zei
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:177569 )

• body weight normal at weaning but weight gain reduced between 5 and 9 weeks of age

• weight returns to normal after 9 weeks

increased liver weight ( J:177569 )

homeostasis/metabolism

increased amino acid betaine level ( J:177569 )

• tissue concentrations of betaine are increased, particularly in the liver

increased circulating alanine transaminase level ( J:177569 )

• modest increase in plasma alanine aminotransferase activity

decreased choline level ( J:177569 )

• reduced tissue concentrations of choline

abnormal lipid level ( J:177569 )

abnormal circulating lipid level ( J:177569 )

• reduced VLDL secretion rate

decreased circulating cholesterol level ( J:177569 )

• significantly reduced plasma total cholesterol levels

decreased circulating HDL cholesterol level ( J:177569 )

• significantly reduced

abnormal phospholipid level ( J:177569 )

• lower levels in the liver

decreased circulating phospholipid level ( J:177569 )

• decreased plasma concentrations

increased triglyceride level ( J:177569 )

• triacylglyceride levels are 6.5 fold greater than in controls at 5 weeks of age

abnormal urine homeostasis ( J:177569 )

• specific gravity significantly reduced

liver/biliary system

abnormal liver morphology ( J:177569 )

• histological abnormalities ranging from preneoplasia to neoplasia

increased liver weight ( J:177569 )

hepatic steatosis ( J:177569 )

• increased

increased liver tumor incidence ( J:177569 )

• visible hepatic tumors in 64% of 1 year old homozygotes, none in controls

increased hepatocellular carcinoma incidence ( J:177569 )

• 50% of homozygotes with hepatocellular carcinomas

increased liver adenoma incidence ( J:177569 )

• 30% of homozygotes with hepatocellular adenomas

renal/urinary system

abnormal urine homeostasis ( J:177569 )

• specific gravity significantly reduced

neoplasm

increased liver tumor incidence ( J:177569 )

• visible hepatic tumors in 64% of 1 year old homozygotes, none in controls

increased hepatocellular carcinoma incidence ( J:177569 )

• 50% of homozygotes with hepatocellular carcinomas

increased liver adenoma incidence ( J:177569 )

• 30% of homozygotes with hepatocellular adenomas