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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcnatm1Tefu
targeted mutation 1, Teizo Fujita
MGI:5297089
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcnatm1Tefu/Fcnatm1Tefu B6.129-Fcnatm1Tefu MGI:5468801
hm2
 		Fcnatm1Tefu/Fcnatm1Tefu involves: 129S4/SvJae MGI:5297094
cx3
 		Fcnatm1Tefu/Fcnatm1Tefu
Fcnbtm1Tefu/Fcnbtm1Tefu 		B6.129-Fcnatm1Tefu Fcnbtm1Yend MGI:5468803
cx4
 		Fcnatm1Tefu/Fcnatm1Tefu
Mbl1tm1Kata/Mbl1tm1Kata
Mbl2tm1Kata/Mbl2tm1Kata 		involves: 129S4/SvJae MGI:5297093


Genotype
MGI:5468801
hm1
Allelic
Composition		 Fcnatm1Tefu/Fcnatm1Tefu
Genetic
Background		 B6.129-Fcnatm1Tefu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcnatm1Tefu mutation (1 available); any Fcna mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired lectin complement pathway ( J:190858 )
• reduced complement 4 deposition although higher than when in conjunction with Fcnbtm1Yend
• reduced complement 3 deposition
increased susceptibility to bacterial infection ( J:190858 )
• higher levels of viable Streptococcus pneumoniae found in lung homogenates after infection
increased susceptibility to bacterial infection induced morbidity/mortality ( J:190858 )
• die in 3-5 days after infection with Streptococcus pneumoniae

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:190858 )
• die in 3-5 days after infection with Streptococcus pneumoniae




Genotype
MGI:5297094
hm2
Allelic
Composition		 Fcnatm1Tefu/Fcnatm1Tefu
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcnatm1Tefu mutation (1 available); any Fcna mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:177350 )
N
• mice exhibit normal collagen antibody-induced arthritis




Genotype
MGI:5468803
cx3
Allelic
Composition		 Fcnatm1Tefu/Fcnatm1Tefu
Fcnbtm1Tefu/Fcnbtm1Tefu
Genetic
Background		 B6.129-Fcnatm1Tefu Fcnbtm1Yend
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcnatm1Tefu mutation (1 available); any Fcna mutation (20 available)
Fcnbtm1Tefu mutation (1 available); any Fcnb mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired lectin complement pathway ( J:190858 )
• reduced complement 4 deposition
• reduced complement 3 deposition
increased susceptibility to bacterial infection ( J:190858 )
• higher levels of viable Streptococcus pneumoniae found in lung homogenates after infection
increased susceptibility to bacterial infection induced morbidity/mortality ( J:190858 )
• die in 3-5 days after infection with Streptococcus pneumoniae

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:190858 )
• die in 3-5 days after infection with Streptococcus pneumoniae




Genotype
MGI:5297093
cx4
Allelic
Composition		 Fcnatm1Tefu/Fcnatm1Tefu
Mbl1tm1Kata/Mbl1tm1Kata
Mbl2tm1Kata/Mbl2tm1Kata
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcnatm1Tefu mutation (1 available); any Fcna mutation (20 available)
Mbl1tm1Kata mutation (1 available); any Mbl1 mutation (23 available)
Mbl2tm1Kata mutation (1 available); any Mbl2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:177350 )
N
• mice exhibit normal collagen antibody-induced arthritis with normal complement alternative pathway activation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory