mortality/aging
• complete lethality around E10 when foster mothers treated with doxycycline throughout development
• early lethality avoided if doxycycline induction delayed until E9.5
|
embryo
• mesoderm development arrested by E12.5 when doxycycline treatment of foster mothers delayed until E9.5
|
• posterior development arrested early when foster mothers treated with doxycycline throughout development
|
• excessive neural tissue at the caudal end of the embry when foster mothers are treated with doxycycline throughout development
|
• absence of notochord caudal to mid brain at E9.5 when foster mothers treated with doxycycline throughout development
|
• notochord development arrested at the mid tail level by E12.5 when doxycycline treatment of foster mothers begins ast E9.5
|
• few irregularly shaped somites when foster mothers treated with doxycycline throughout development
|
• absence of allantois derivatives when foster mothers treated with doxycycline throughout development
|
nervous system
• excessive neural tissue at the caudal end of the embry when foster mothers are treated with doxycycline throughout development
|