Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm5(tetO-RNAi:T)Bgh}
• Allele Name: targeted mutation 5, Bernhard G Herrmann
• Allele ID: MGI:5297162
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm5(tetO-RNAi:T)Bgh/Gt(ROSA)26Sor^+	chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1	MGI:5297170

Genotype
MGI:5297170

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm5(tetO-RNAi:T)Bgh}/Gt(ROSA)26Sor⁺
• Genetic Background: chimera involves: C57BL/6 or (129S6/SvEvTac x C57BL/6NCr)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:173434 )

• early lethality avoided if doxycycline induction delayed until E9.5

• complete lethality around E10 when foster mothers treated with doxycycline throughout development

embryo

abnormal mesoderm development ( J:173434 )

• mesoderm development arrested by E12.5 when doxycycline treatment of foster mothers delayed until E9.5

caudal body truncation ( J:173434 )

• posterior development arrested early when foster mothers treated with doxycycline throughout development

abnormal neural tube morphology ( J:173434 )

• excessive neural tissue at the caudal end of the embry when foster mothers are treated with doxycycline throughout development

absent notochord ( J:173434 )

• absence of notochord caudal to mid brain at E9.5 when foster mothers treated with doxycycline throughout development

truncated notochord ( J:173434 )

• notochord development arrested at the mid tail level by E12.5 when doxycycline treatment of foster mothers begins ast E9.5

impaired somite development ( J:173434 )

• few irregularly shaped somites when foster mothers treated with doxycycline throughout development

absent allantois ( J:173434 )

• absence of allantois derivatives when foster mothers treated with doxycycline throughout development

nervous system

abnormal neural tube morphology ( J:173434 )

• excessive neural tissue at the caudal end of the embry when foster mothers are treated with doxycycline throughout development