Phenotypes associated with this allele

• Allele Symbol: Snap25^tm1Mtaka
• Allele Name: targeted mutation 1, Masami Takahashi
• Allele ID: MGI:5297219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snap25^tm1Mtaka/Snap25^tm1Mtaka	B6N.129P2-Snap25^tm1Mtaka	MGI:5297222

Genotype
MGI:5297222

hm1

• Allelic Composition: Snap25^tm1Mtaka/Snap25^tm1Mtaka
• Genetic Background: B6N.129P2-Snap25^tm1Mtaka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal locomotor activity in open field in Snap25^tm1Mtaka/Snap25^tm1Mtaka mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:177870 )

• some mice die between 2 and 3 weeks of age

behavior/neurological

increased anxiety-related response ( J:177870 )

• in a light-dark tests, mice spend more time in the dark component compared with wild-type mice

increased thigmotaxis ( J:177870 )

• in an open field test

abnormal impulsive behavior control ( J:177870 )

• mice jump off platforms without hesitation unlike wild-type mice

abnormal locomotor behavior ( J:177870 )

• in an open field test, mice exhibit increased variability in locomotion unlike wild-type mice

decreased vertical activity ( J:177870 )

• gradually over time in an open field test

increased locomotor activity ( J:177870 )

• in an open field test, mice exhibit increased individual time spent moving and increased velocity compared with wild-type mice

• in a light-dark test, mice exhibit higher activity and velocity compared with wild-type mice

convulsive seizures ( J:177870 )

• after postnatal day 21 and 24, some mice exhibit spontaneous convulsive seizures unlike wild-type mice

homeostasis/metabolism

abnormal dopamine level ( J:177870 )

• spontaneous dopamine release in the amygdala is reduced compared to in wild-type mice

• however, brain dopamine content is normal

abnormal serotonin level ( J:177870 )

• spontaneous serotonin release in the amygdala is reduced compared to in wild-type mice

• however, brain serotonin content is normal

nervous system

convulsive seizures ( J:177870 )

• after postnatal day 21 and 24, some mice exhibit spontaneous convulsive seizures unlike wild-type mice