Phenotypes associated with this allele

• Allele Symbol: Epb41l3^tm1.1Jglt
• Allele Name: targeted mutation 1.1, Jean-Antoine Girault
• Allele ID: MGI:5297225
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt	involves: FVB/N	MGI:5297239

Genotype
MGI:5297239

hm1

• Allelic Composition: Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Limb clasping and gait abnormalities in Epb41l3^tm1.1Jglt/Epb41l3^tm1.1Jglt mice

mortality/aging

premature death ( J:177866 )

nervous system

abnormal axon morphology ( J:177866 )

• motor axons exhibit decreased axonal diameter and are irregularly swollen with alternating narrow segments compared with wild-type axons

• mice exhibit alteration of preterminal axons of motor endplates compared with wild-type mice

abnormal internode morphology ( J:177866 )

• intermodal length is slightly decreased compared to in wild-type mice

hypermyelination ( J:177866 )

• myelin thickness is increased compared to in wild-type mice

abnormal nervous system electrophysiology ( J:177866 )

• nerves exhibit transient temperature sensitive hyperexcitability compared with wild-type nerves

• however, nerve conduction is normal

behavior/neurological

behavior/neurological phenotype ( J:177866 )

N • mice exhibit normal grip strength and nociception

limb grasping ( J:177866 )

ataxia ( J:177866 )

• mild

abnormal gait ( J:177866 )

• mice exhibit slight gait abnormalities with short stride length and increased alternation coefficient compared with wild-type mice

• however, stride width is normal

short stride length ( J:177866 )