All Phenotypes Gab2<tm4.1Thir> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gab2^tm4.1Thir
targeted mutation 4.1, Toshio Hirano
MGI:5297248

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gab2^tm4.1Thir/Gab2^tm4.1Thir	involves: 129T/SvJcl * C57BL/6Jcl	MGI:5297353

Allelic Composition	Gab2^tm4.1Thir/Gab2^tm4.1Thir
Genetic Background	involves: 129T/SvJcl * C57BL/6Jcl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab2^tm4.1Thir mutation (1 available); any Gab2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:178045 )

N	• bone marrow-derived mast cells exhibit normal Fcer1-induced cytokine production

decreased mast cell degranulation ( J:178045 )

decreased mast cell number ( J:178045 )

• in mucosal mast cells, but not skin mast cells

• IgE-mediated

hematopoietic system

decreased mast cell degranulation ( J:178045 )

decreased mast cell number ( J:178045 )

• in mucosal mast cells, but not skin mast cells

cellular

decreased mast cell degranulation ( J:178045 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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