Phenotypes associated with this allele

• Allele Symbol: Il17c^tm1.1Cdon
• Allele Name: targeted mutation 1.1, Chen Dong
• Allele ID: MGI:5297496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17c^tm1.1Cdon/Il17c^tm1.1Cdon	involves: 129S6/SvEvTac	MGI:5297498

Genotype
MGI:5297498

hm1

• Allelic Composition: Il17c^tm1.1Cdon/Il17c^tm1.1Cdon
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:177650 )

• with fewer total numbers of IL17A-, IFNG-, and IL17A/IFNG-producing CD4+ T cells following induction of experimental autoimmune encephalomyelitis

decreased interferon-gamma secretion ( J:177650 )

• fewer total numbers of IFNG- and IL17A/IFNG-producing CD4+ T cells following induction of experimental autoimmune encephalomyelitis

decreased interleukin-17 secretion ( J:177650 )

• fewer total numbers of IL17A- and IL17A/IFNG-producing CD4+ T cells following induction of experimental autoimmune encephalomyelitis

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:177650 )

• fewer mice develop induce-experimental autoimmune encephalomyelitis symptoms with reduced severity compared with similarly treated wild-type mice

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:177650 )

• with fewer total numbers of IL17A-, IFNG-, and IL17A/IFNG-producing CD4+ T cells following induction of experimental autoimmune encephalomyelitis