Phenotypes associated with this allele

• Allele Symbol: Inpp4b^tm1.1Jva
• Allele Name: targeted mutation 1.1, Jean Vacher
• Allele ID: MGI:5297505
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inpp4b^tm1.1Jva/Inpp4b^tm1.1Jva	B6.129-Inpp4b^tm1.1Jva	MGI:5297506

Genotype
MGI:5297506

hm1

• Allelic Composition: Inpp4b^tm1.1Jva/Inpp4b^tm1.1Jva
• Genetic Background: B6.129-Inpp4b^tm1.1Jva

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:177648 )

• mice exhibit a 2- to 3-fold increased in osteoclast size and number compared with wild-type mice

abnormal osteoclast differentiation ( J:177648 )

• bone marrow cells exhibit increased production of osteoblast cells (1.7-fold) with increased size (3-fold) compared with those produced by wild-type bone marrow cells

• however, osteoclast activity is normal

increased osteoclast cell number ( J:177648 )

• 2- to 3-fold

short humerus ( J:177648 )

short ulna ( J:177648 )

short femur ( J:177648 )

short tibia ( J:177648 )

decreased bone mineral density of femur ( J:177648 )

• decreased bone mineral density in the femur

decreased bone volume ( J:177648 )

• in bone volume fraction at 8 weeks and 4 months

increased osteoblast cell number ( J:177648 )

abnormal trabecular bone morphology ( J:177648 )

• increased trabecular space at 8 weeks

• decreased trabecular space at 4 months

increased bone trabecula number ( J:177648 )

• at 8 weeks

increased trabecular bone thickness ( J:177648 )

• at 4 months

osteoporosis ( J:177648 )

abnormal bone mineralization ( J:177648 )

• mice exhibit increased mineral apposition rate compared with wild-type mice

increased bone resorption ( J:177648 )

immune system

abnormal osteoclast morphology ( J:177648 )

• mice exhibit a 2- to 3-fold increased in osteoclast size and number compared with wild-type mice

abnormal osteoclast differentiation ( J:177648 )

• bone marrow cells exhibit increased production of osteoblast cells (1.7-fold) with increased size (3-fold) compared with those produced by wild-type bone marrow cells

• however, osteoclast activity is normal

increased osteoclast cell number ( J:177648 )

• 2- to 3-fold

limbs/digits/tail

short humerus ( J:177648 )

short ulna ( J:177648 )

short femur ( J:177648 )

short tibia ( J:177648 )

hematopoietic system

abnormal osteoclast morphology ( J:177648 )

• mice exhibit a 2- to 3-fold increased in osteoclast size and number compared with wild-type mice

abnormal osteoclast differentiation ( J:177648 )

• bone marrow cells exhibit increased production of osteoblast cells (1.7-fold) with increased size (3-fold) compared with those produced by wild-type bone marrow cells

• however, osteoclast activity is normal

increased osteoclast cell number ( J:177648 )

• 2- to 3-fold

cellular

abnormal osteoclast differentiation ( J:177648 )

• bone marrow cells exhibit increased production of osteoblast cells (1.7-fold) with increased size (3-fold) compared with those produced by wild-type bone marrow cells

• however, osteoclast activity is normal