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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aqp4tm1.1Geno
targeted mutation 1.1, Genoway
MGI:5297539
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Aqp4tm1.1Geno/Aqp4tm1.1Geno
Tg(GFAP-cre)25Mes/0 		involves: C57BL/6J * FVB/N MGI:5297540


Genotype
MGI:5297540
cn1
Allelic
Composition		 Aqp4tm1.1Geno/Aqp4tm1.1Geno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp4tm1.1Geno mutation (0 available); any Aqp4 mutation (46 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood-brain barrier function ( J:177412 )
• after water injection, mice exhibit decreased water uptake compared with similarly treated wild-type mice
• basal brain water content is increased compared to in wild-type mice
• however, the blood-brain barrier is intake in a Evans dye transfer assay

nervous system
abnormal blood-brain barrier function ( J:177412 )
• after water injection, mice exhibit decreased water uptake compared with similarly treated wild-type mice
• basal brain water content is increased compared to in wild-type mice
• however, the blood-brain barrier is intake in a Evans dye transfer assay




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory