Phenotypes associated with this allele

• Allele Symbol: Ighm^tm1Bhe
• Allele Name: targeted mutation 1, Birgitta Heyman
• Allele ID: MGI:5297544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighm^tm1Bhe/Ighm^tm1Bhe	C.Cg-Ighm^tm1Bhe	MGI:5297545

Genotype
MGI:5297545

hm1

• Allelic Composition: Ighm^tm1Bhe/Ighm^tm1Bhe
• Genetic Background: C.Cg-Ighm^tm1Bhe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal complement pathway ( J:177421 )

• IgM specific for sheep RBCs fails to activate complement

• IgM is unable to initiate C3 deposition on sheep RBCs

• IgG responses to sheep RBCs is unaffected

• IgG responses to keyhole limpet hemocyanin are also unaffected

impaired complement classical pathway ( J:177421 )

abnormal immune serum protein physiology ( J:177421 )

• IgM specific for sheep RBCs fails to activate complement

• IgM is unable to initiate C3 deposition on sheep RBCs

• IgG responses to sheep RBCs is unaffected

• IgG responses to keyhole limpet hemocyanin are also unaffected