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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sirt2tm1.1Cxd
targeted mutation 1.1, Chu-Xia Deng
MGI:5297582
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sirt2tm1.1Cxd/Sirt2tm1.1Cxd either: (involves: C57BL/6 * FVB/N) or (involves: FVB/N * NIH Black Swiss) MGI:5297585


Genotype
MGI:5297585
hm1
Allelic
Composition
Sirt2tm1.1Cxd/Sirt2tm1.1Cxd
Genetic
Background
either: (involves: C57BL/6 * FVB/N) or (involves: FVB/N * NIH Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt2tm1.1Cxd mutation (0 available); any Sirt2 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 8 months in some male mice
• at 10 months in some female mice, primarily in the mammary glands
• at 20 months in more male mice in the liver, lung, pancreas, stomach, duodenum, and prostate
• at 24 in most female mice
• stomach tumor in one male mouse
• duodenum tumor in one male mice
• in one female and male mice
• poorly differentiated, with obvious nuclear polymorphisms
• in one female and male mice
• in some mice with extensive cellular proliferation
• in female and male mice

cellular
• in 35% of mouse embryonic fibroblasts
• in mouse embryonic fibroblasts
• in mouse embryonic fibroblasts
• mouse embryonic fibroblasts cease proliferating one passage before wild-type cells

endocrine/exocrine glands
• poorly differentiated, with obvious nuclear polymorphisms
• prior to tumor development
• in one female and male mice

integument
• poorly differentiated, with obvious nuclear polymorphisms
• prior to tumor development

reproductive system

digestive/alimentary system
• stomach tumor in one male mouse
• duodenum tumor in one male mice
• in one female and male mice

respiratory system
• in female and male mice

liver/biliary system
• in some mice with extensive cellular proliferation





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory