neoplasm
• at 8 months in some male mice
• at 10 months in some female mice, primarily in the mammary glands
• at 20 months in more male mice in the liver, lung, pancreas, stomach, duodenum, and prostate
• at 24 in most female mice
|
• stomach tumor in one male mouse
• duodenum tumor in one male mice
|
• in one female and male mice
|
• poorly differentiated, with obvious nuclear polymorphisms
|
• in one male mouse
|
• in one female and male mice
|
• in some mice with extensive cellular proliferation
|
• in one female mice
|
• in female and male mice
|
cellular
aneuploidy
(
J:177486
)
• in 35% of mouse embryonic fibroblasts
|
• in mouse embryonic fibroblasts
|
• in mouse embryonic fibroblasts
|
• mouse embryonic fibroblasts cease proliferating one passage before wild-type cells
|
endocrine/exocrine glands
• poorly differentiated, with obvious nuclear polymorphisms
|
• prior to tumor development
|
• in one male mouse
|
• in one female and male mice
|
integument
• poorly differentiated, with obvious nuclear polymorphisms
|
• prior to tumor development
|
reproductive system
• in one male mouse
|
digestive/alimentary system
• stomach tumor in one male mouse
• duodenum tumor in one male mice
|
• in one female and male mice
|
respiratory system
• in female and male mice
|
liver/biliary system
• in some mice with extensive cellular proliferation
|