Analysis Tools
mortality/aging
 |
• about 25% of females survive beyond 4 weeks of age
|
|
|
• 45% of females die within the first 4 days after birth, followed by a lower rate of death until day 24 after which no substantial lethality is seen
|
growth/size/body
|
|
• 15% of females exhibit complete cleft palate at E18.5
|
|
|
• pups that die but have no cleft palate have a lower body weight than pups that survive
|
|
|
• females show normal birth weight, however at 2 weeks of age, females weight nearly 50% less than wild-type females, indicating postnatal developmental delay
• after weaning at 3 weeks of age, females grow and have a similar body weight to wild-type mice at 6 weeks of age
|
behavior/neurological
|
|
• 30 of 35 females exhibit handling seizures
|
|
|
• 6 month old mice display handling and/or audiogenic seizures
|
|
|
• females exhibit spontaneous seizures
• spontaneous seizures appear as periods of rhythmic repetitive spike and sharp wave activity and appear to be of limbic origin
|
craniofacial
|
|
• 15% of females exhibit complete cleft palate at E18.5
|
digestive/alimentary system
|
|
• 15% of females exhibit complete cleft palate at E18.5
|
nervous system
|
|
• 30 of 35 females exhibit handling seizures
|
|
|
• 6 month old mice display handling and/or audiogenic seizures
|
|
|
• females exhibit spontaneous seizures
• spontaneous seizures appear as periods of rhythmic repetitive spike and sharp wave activity and appear to be of limbic origin
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| chromosomal deletion syndrome | DOID:0060388 | J:210663 | ||
