All Phenotypes Nkx2-2<tm2.1Suss> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx2-2^tm2.1Suss
targeted mutation 2.1, Lori Sussel
MGI:5297810

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL	MGI:5297818
cn2	Arx^tm1Gldn/Arx^tm1Gldn Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0	involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL	MGI:5297819
cn3	Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0	involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL	MGI:5297821
cn4	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdx1-cre/Esr1*)#Dam/0	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL	MGI:5297840
cn5	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)23Herr/0	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL	MGI:5297841
cn6	Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0	involves: Black Swiss * C57BL/6 * CBA/J * SJL	MGI:5297820

Allelic Composition	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:177838 )

• mice do not survive beyond 8 weeks of age

reproductive system

reduced female fertility ( J:177838 )

• at 6 weeks of age

reduced male fertility ( J:177838 )

• at 6 weeks of age

endocrine/exocrine glands

increased pancreatic alpha cell number ( J:177838 )

• at E18.5 and 4 weeks of age

decreased pancreatic beta cell number ( J:177838 )

• beginning at E13.5 and 4 weeks of age

increased pancreatic epsilon cell number ( J:177838 )

• at E13.5, E15.5, and E18.5

small pancreatic islets ( J:177838 )

disorganized pancreatic islets ( J:177838 )

homeostasis/metabolism

hyperglycemia ( J:177838 )

• in male mice at 3.5 week

• in male and female mice at 7 weeks of age

• at 6 weeks of age, female and male mice are severely diabetic under fed and fasted conditions unlike wild-type mice

Allelic Composition	Arx^tm1Gldn/Arx^tm1Gldn Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arx^tm1Gldn mutation (0 available); any Arx mutation (20 available)
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:177838 )

N	• beta cell do not transdifferentiate into alpha cells unlike in Nkx2-2^tm2.1Suss homozygotes

decreased pancreatic beta cell number ( J:177838 )

• at E18.5

homeostasis/metabolism

hyperglycemia ( J:177838 )

Allelic Composition	Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm1Jae mutation (1 available); any Dnmt3a mutation (139 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:177838 )

• mice exhibit beta to alpha cell transdifferentiation

cellular

abnormal pancreatic beta cell differentiation ( J:177838 )

• mice exhibit beta to alpha cell transdifferentiation

Allelic Composition	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdx1-cre/Esr1*)#Dam/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Pdx1-cre/Esr1*)#Dam mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:177838 )

• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming

cellular

abnormal pancreatic beta cell differentiation ( J:177838 )

• mice treated with tamoxifen at 3 weeks of age exhibit beta cells to alpha cells reprogramming

Allelic Composition	Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell differentiation ( J:177838 )

• beta cells are reprogrammed to alpha cells

cellular

abnormal pancreatic beta cell differentiation ( J:177838 )

• beta cells are reprogrammed to alpha cells

Allelic Composition	Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0
Genetic Background	involves: Black Swiss * C57BL/6 * CBA/J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm1Jae mutation (1 available); any Dnmt3a mutation (139 available)
Nkx2-2^tm2.1Suss mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic alpha cell number ( J:177838 )

decreased pancreatic beta cell number ( J:177838 )

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