Phenotypes associated with this allele

• Allele Symbol: Lrrc7^tm1.1Mabk
• Allele Name: targeted mutation 1.1, Mary B Kennedy
• Allele ID: MGI:5297824
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk	B6.129S1-Lrrc7^tm1.1Mabk	MGI:5297852
hm2	Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk	involves: 129S1/Sv * FVB/N	MGI:5297850
cx3	Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk Tg(Thy1-EGFP)MJrs/0	involves: 129S1/Sv * C57BL/6J * CBA * FVB/N	MGI:5297851

Genotype
MGI:5297852

hm1

• Allelic Composition: Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk
• Genetic Background: B6.129S1-Lrrc7^tm1.1Mabk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:177836 )

• mice exhibit a 3-fold reduction in the amount of time engaged in high-energy behaviors compared with wild-type mice

abnormal short-term spatial reference memory ( J:177836 )

• mice spend less time exploring an objected moved to a novel location compared with wild-type mice

increased aggression towards mice ( J:177836 )

• when mice are co-housed together or with heterozygous or wild-type mice

increased thigmotaxis ( J:177836 )

abnormal response to novel object ( J:177836 )

• mice spend less time exploring a novel object compared with wild-type mice

abnormal locomotor activation ( J:177836 )

• mice exhibit hyperlocomotion when interacting with the objects during the short-term memory tasks compared with wild-type mice

• in response to a novel or stressful situations, mice become hyperactive compared with wild-type mice

• in a familiar environment, mice become more sedentary than wild-type mice

increased locomotor activity ( J:177836 )

• mice exhibit hypelocomotion when interacting with the objects during the short-term memory tasks compared with wild-type mice

• in response to a novel or stressful situations, mice become hyperactive compared with wild-type mice

abnormal sleep behavior ( J:177836 )

• mice exhibit a 2-fold increase in twitching during resting periods compared with wild-type mice

• however, the amount of time spent sleeping is normal

abnormal nest building behavior ( J:177836 )

• only 1 of 16 mice shredded cotton within 72 h compared with wild-type mice that make nests within 24 hours

nervous system

decreased prepulse inhibition ( J:177836 )

Genotype
MGI:5297850

hm2

• Allelic Composition: Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

premature death ( J:177836 )

• some mice die between 2 and 6 weeks

nervous system

nervous system phenotype ( J:177836 )

N • synaptic transmission is normal

reduced long-term depression ( J:177836 )

• NMDAR-dependent or mGluR-dependent

behavior/neurological

limb grasping ( J:177836 )

growth/size/body

decreased body weight ( J:177836 )

• between 2 and 6 weeks of age

Genotype
MGI:5297851

cx3

• Allelic Composition: Lrrc7^tm1.1Mabk/Lrrc7^tm1.1Mabk; Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA * FVB/N

nervous system

abnormal dendritic spine morphology ( J:177836 )

• the necks of dendritic spines exhibit decreased neck diameter compared to in wild-type mice

• the proportion of mushroom spines in increased while the number of stubby spines is decreased compared to in wild-type mice

• spine length on mushroom spines is increased compared to in wild-type mice

• however, the total number of spines is normal