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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map2k7tm1Rjd
targeted mutation 1, Roger J Davis
MGI:5297854
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0 		involves: C3H * C57BL/6 * FVB/N MGI:5297909
cn2
 		Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:5297907
cn3
 		Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:5297908


Genotype
MGI:5297909
cn1
Allelic
Composition		 Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(APPswe,PSEN1dE9)85Dbo/0
Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic
Background		 involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (33 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (20 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (6 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:178060 )
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
abnormal neurite morphology ( J:178060 )
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo

homeostasis/metabolism
amyloid beta deposits ( J:178060 )
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo




Genotype
MGI:5297907
cn2
Allelic
Composition		 Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (20 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:178060 )
N
• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation




Genotype
MGI:5297908
cn3
Allelic
Composition		 Map2k4tm1Ctr/Map2k4tm1Ctr
Map2k7tm1Rjd/Map2k7tm1Rjd
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation (0 available); any Map2k4 mutation (33 available)
Map2k7tm1Rjd mutation (0 available); any Map2k7 mutation (20 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased neuron apoptosis ( J:178060 )
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons

nervous system
decreased neuron apoptosis ( J:178060 )
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory