Phenotypes associated with this allele

• Allele Symbol: Taar1^tm1Mmil
• Allele Name: targeted mutation 1, Mark J Millan
• Allele ID: MGI:5297915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taar1^tm1Mmil/Taar1^tm1Mmil	B6.129S2-Taar1^tm1Mmil	MGI:5297920

Genotype
MGI:5297920

hm1

• Allelic Composition: Taar1^tm1Mmil/Taar1^tm1Mmil
• Genetic Background: B6.129S2-Taar1^tm1Mmil

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased core body temperature ( J:178061 )

• MDMA-treated mice exhibit long-lasting hyperthermia unlike wild-type mice

increased dopamine level ( J:178061 )

• in the dorsal striatum, nucleus accumbens, and frontal cortex of MDMA-treated mice

increased serotonin level ( J:178061 )

• in the dorsal striatum and nucleus accumbens of MDMA-treated mice

decreased physiological sensitivity to xenobiotic ( J:178061 )

• o-PIT, a Taar1 agonist, does not affect dopamine or serotonin release

increased physiological sensitivity to xenobiotic ( J:178061 )

• MDMA-treated mice exhibit increased hyperthermia, dopamine levels in the dorsal striatum, nucleus accumbens, and frontal cortex, serotonin in the dorsal striatum and nucleus accumbens, and induced-hyperlocomotion compared with similarly treated wild-type mice

• haloperidol produces a more potent reduction in MDMA-induced hyperlocomotion than in similarly treated wild-type mice

behavior/neurological

induced hyperactivity ( J:178061 )

• in mice treated with MDMA