All Phenotypes Tg(RNU6-RNAi:Mpp5)13Wij MGI Mouse

abnormal ocular fundus morphology ( J:178056 )

• at 1 and 3 months of age, ocular fundus exhibit sites of cellular mislocalization and roundish structures in the outer plexiform layer unlike wild-type mice

• at 6 and 12 months of age, the ocular fundus has spotty and patchy areas with vascular leakage unlike in wild-type mice

abnormal retina morphology ( J:178056 )

• at P10, retinal basal infoldings are disorganization and vacuoles are increased in number and size compared with wild-type mice

• mice exhibit a stronger phenotype than in Tg(Chx10-EGFP/cre,-ALPP)2Clc Tg(RNU6-RNAi:Mpp5)13Wij mice

abnormal retina bipolar cell morphology ( J:178056 )

• bipolar cells are ectopically localized in the outer nuclear layer

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

abnormal retina pigment epithelium morphology ( J:178056 )

• the apical microvilli of the retinal pigment epithelium are either absent or shorter and did not interdigitate with the outer segments of photoreceptor cells compared to in wild-type mice

abnormal retina neuronal layer morphology ( J:178056 )

• from P10 to P30, mice exhibit folds between the retinal outer and inner layers (ONL and INL) and retinal outer plexiform layer (OPL), half rosettes of photoreceptors in the ONL and OPL, and ectopic photoreceptor nuclei in the subretinal space unlike wild-type mice

abnormal retina photoreceptor morphology ( J:178056 )

• ectopically localized in the subretinal space or outer plexiform layer

short photoreceptor outer segment ( J:178056 )

• in the cone outer segments at P30

retina photoreceptor degeneration ( J:178056 )

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

thin retina inner nuclear layer ( J:178056 )

• progressively thinner in aged mice

disorganized retina inner nuclear layer ( J:178056 )

• at P6

thin retina outer nuclear layer ( J:178056 )

• progressively thinner in aged mice

disorganized retina outer nuclear layer ( J:178056 )

• at P6

abnormal retina outer plexiform layer morphology ( J:178056 )

• with roundish structures at 1 and 3 months

disorganized retina outer plexiform layer ( J:178056 )

• at P6

disorganized retina layers ( J:178056 )

abnormal retina outer limiting membrane morphology ( J:178056 )

• with gaps and irregularities

retina degeneration ( J:178056 )

abnormal eye electrophysiology ( J:178056 )

• mice exhibit reduced scotopic and photopic responses and lowered a- and b-wave amplitudes compared with wild-type mice

abnormal cone electrophysiology ( J:178056 )

• mice exhibit reduced photopic response compared with wild-type mice

abnormal rod electrophysiology ( J:178056 )

• mice exhibit reduced scotopic response compared with wild-type mice

increased neuron apoptosis ( J:178056 )

• at P10, mice exhibit persistent apoptosis of photoreceptors and bipolar cells unlike wild-type mice

• at P18, mice exhibit increased apoptosis in the outer and inner nuclear layer compared with wild-type mice

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

gliosis ( J:178056 )

abnormal retina bipolar cell morphology ( J:178056 )

• bipolar cells are ectopically localized in the outer nuclear layer

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

abnormal retina photoreceptor morphology ( J:178056 )

• ectopically localized in the subretinal space or outer plexiform layer

short photoreceptor outer segment ( J:178056 )

• in the cone outer segments at P30

retina photoreceptor degeneration ( J:178056 )

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

increased vascular permeability ( J:178056 )

• vascular leakage in the ocular fundus at 6 and 12 months of age

increased neuron apoptosis ( J:178056 )

• at P10, mice exhibit persistent apoptosis of photoreceptors and bipolar cells unlike wild-type mice

• at P18, mice exhibit increased apoptosis in the outer and inner nuclear layer compared with wild-type mice

• at 3, 6, and 12 months, mice exhibit loss of photoreceptors and bipolar cells due to apoptosis compared with wild-type mice

abnormal retina pigment epithelium morphology ( J:178056 )

• the apical microvilli of the retinal pigment epithelium are either absent or shorter and did not interdigitate with the outer segments of photoreceptor cells compared to in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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