Phenotypes associated with this allele

• Allele Symbol: Gria4^tm1Yfkk
• Allele Name: targeted mutation 1, Yasuyuki Fukumaki
• Allele ID: MGI:5298021
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria4^tm1Yfkk/Gria4^tm1Yfkk	B6.129S-Gria4^tm1Yfkk	MGI:5298026

Genotype
MGI:5298026

hm1

• Allelic Composition: Gria4^tm1Yfkk/Gria4^tm1Yfkk
• Genetic Background: B6.129S-Gria4^tm1Yfkk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:178206 )

N • mice exhibit normal righting reflex, whisker touch reflex, ear twitch reflex, activity in an open field test, anxiety-related behavior in a novel environment or in an elevated plus maze, performance in a wire hang test, learning and memory performance in an eight-arm radial maze test, and circadian rhythms

abnormal spatial reference memory ( J:178206 )

• in a Barnes circular maze, acquisition of spatial reference memory is impaired compared with wild-type mice

• however, consolidation and retention are normal

enhanced spatial working memory ( J:178206 )

• mildly improved spatial working memory only in the task with no delay in a T maze

increased anxiety-related response ( J:178206 )

• in a light-dark test, mice exhibit fewer transition into the light section compared with wild-type mice

• however, other tests for anxiety-related behavior are normal

decreased startle reflex ( J:178206 )

decreased grip strength ( J:178206 )

decreased vertical activity ( J:178206 )

• in an open field test

increased vertical activity ( J:178206 )

• induced by MK-801

induced hyperactivity ( J:178206 )

• induced by MK-801

• however, spontaneous locomotor activity is normal

abnormal social investigation ( J:178206 )

• duration of contact is increased compared to wild-type mice

growth/size/body

decreased body weight ( J:178206 )

• 10% less

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:178206 )

• MK-801-treated mice exhibit increased horizontal and vertical activity compared with wild-type mice

• however, time spent in the center of the area is normal

nervous system

nervous system phenotype ( J:178206 )

N • mice exhibit normal long term potentiation

decreased prepulse inhibition ( J:178206 )