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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Clec9atm1.1Crs
targeted mutation 1.1, Caetano Reis e Sousa
MGI:5298406
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Clec9atm1.1Crs/Clec9atm1.1Crs C57BL/6-Clec9atm1.1Crs MGI:5298484


Genotype
MGI:5298484
hm1
Allelic
Composition		 Clec9atm1.1Crs/Clec9atm1.1Crs
Genetic
Background		 C57BL/6-Clec9atm1.1Crs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clec9atm1.1Crs mutation (3 available); any Clec9a mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell antigen presentation ( J:178441 )
• CD8alpha+ dendritic cells have a specific defect in efficient cross-presentation of dead-cell associated antigens both in vitro and in vivo
• CD8alpha+ dendritic cells are able to uptake necrotic cells, present soluble antigen, and present antigen conjugated to beads (a model of cross presentation)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory