Phenotypes associated with this allele

• Allele Symbol: Kiss1^{tm1.1(cre/EGFP)Stei}
• Allele Name: targeted mutation 1.1, Robert A Steiner
• Allele ID: MGI:5298495
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kiss1^tm1.1(cre/EGFP)Stei/Kiss1^+	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5449629

Genotype
MGI:5449629

ht1

• Allelic Composition: Kiss1^{tm1.1(cre/EGFP)Stei}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:178519 )

♀N • Kiss1 neurons (neurons labeling for GFP) in the arcuate nucleui (ARC) of ovariectomized adult females express a hyperpolarization induced cation current (h current) and a transient Ca²⁺ current (T-type current) which are pacemaker currents, mRNA expression of Cnga1 (HCN) and Cacna1g (voltage-dependent calcium channel, T type, alpha 1G subunit) which underlie pacemaker currents, and show NMDA-induced burst firing activity; these data corroborate findings in the ARC of guinea pigs