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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dppa4tm1Yam
targeted mutation 1, Shinya Yamanaka
MGI:5298638
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dppa2tm1Yam/Dppa2tm1Yam
Dppa4tm1Yam/Dppa4tm1Yam 		involves: 129S4/SvJae MGI:5298647
cx2
 		Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam 		involves: 129S4/SvJae MGI:5298648


Genotype
MGI:5298647
cx1
Allelic
Composition		 Dppa2tm1Yam/Dppa2tm1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:178324 )
• viable and fertile with no gross abnormalities




Genotype
MGI:5298648
cx2
Allelic
Composition		 Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:178324 )
• cyanotic pups die within 2h of birth

respiratory system
respiratory failure ( J:178324 )
• seen in pups that die within 2h of birth

homeostasis/metabolism
cyanosis ( J:178324 )
• displayed by some pups

cellular
decreased cell proliferation ( J:178324 )
• slower proliferation of cultured embryonic stem cells compared to controls
abnormal DNA methylation ( J:178324 )
• methylation status of some genes is altered in cultured embryonic stem cells compared to controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory