All Phenotypes Dppa2<tm1.2Yam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dppa2^tm1.2Yam
targeted mutation 1.2, Shinya Yamanaka
MGI:5298642

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dppa2^tm1.2Yam/Dppa2^tm1.2Yam Dppa4^tm1.1Yam/Dppa4^tm1.1Yam	involves: 129S4/SvJae * FVB/N	MGI:5298644

Allelic Composition	Dppa2^tm1.2Yam/Dppa2^tm1.2Yam Dppa4^tm1.1Yam/Dppa4^tm1.1Yam
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2^tm1.2Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4^tm1.1Yam mutation (2 available); any Dppa4 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:178324 )

• at weaning, only 3.3% of pups are double homozygotes

perinatal lethality, incomplete penetrance ( J:178324 )

prenatal lethality, incomplete penetrance ( J:178324 )

• slightly fewer embryos than expected are detected at E18.5

respiratory system

abnormal lung morphology ( J:178324 )

• at E18.5 the lung mesenchyme is slightly thicker compared to controls

growth/size/body

decreased birth weight ( J:178324 )

slow postnatal weight gain ( J:178324 )

• surviving mice weigh less at 5, 10 and 15 weeks of age but catch up to controls by 20 weeks of age

reproductive system

reproductive system phenotype ( J:178324 )

N	• surviving adults are fertile

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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