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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dppa2tm1.1Yam
targeted mutation 1.1, Shinya Yamanaka
MGI:5298643
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
involves: 129S4/SvJae MGI:5298648
cx2
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.2Yam/Dppa4tm1.2Yam
involves: 129S4/SvJae * FVB/N MGI:5298645
cx3
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
involves: 129S4/SvJae * FVB/N MGI:5298646


Genotype
MGI:5298648
cx1
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• cyanotic pups die within 2h of birth

respiratory system
• seen in pups that die within 2h of birth

homeostasis/metabolism
• displayed by some pups

cellular
• slower proliferation of cultured embryonic stem cells compared to controls
• methylation status of some genes is altered in cultured embryonic stem cells compared to controls




Genotype
MGI:5298645
cx2
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.2Yam mutation (0 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer embryos than expected are detected at E18.5
• no double homozygotes pups are found at weaning

respiratory system
• at E18.5 the lung mesenchyme is thicker compared to controls
• smaller alveolar spaces at E18.5




Genotype
MGI:5298646
cx3
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.1Yam mutation (2 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at weaning, only 2.9% of pups are double homozygotes
• fewer than expected found at birth
• however, expected numbers are found at E18.5

respiratory system
• at E18.5 the lung mesenchyme is thicker compared to controls
• severity of the increase in thickness is variable
• smaller alveolar spaces at E18.5
• severity of the decrease in size is variable

growth/size/body

reproductive system
N
• surviving adults are fertile





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory