About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dppa2tm1.1Yam
targeted mutation 1.1, Shinya Yamanaka
MGI:5298643
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
involves: 129S4/SvJae MGI:5298648
cx2
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.2Yam/Dppa4tm1.2Yam
involves: 129S4/SvJae * FVB/N MGI:5298645
cx3
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
involves: 129S4/SvJae * FVB/N MGI:5298646


Genotype
MGI:5298648
cx1
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1Yam/Dppa4tm1Yam
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1Yam mutation (1 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• cyanotic pups die within 2h of birth

respiratory system
• seen in pups that die within 2h of birth

homeostasis/metabolism
• displayed by some pups

cellular
• slower proliferation of cultured embryonic stem cells compared to controls
• methylation status of some genes is altered in cultured embryonic stem cells compared to controls




Genotype
MGI:5298645
cx2
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.2Yam/Dppa4tm1.2Yam
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.2Yam mutation (0 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer embryos than expected are detected at E18.5
• no double homozygotes pups are found at weaning

respiratory system
• at E18.5 the lung mesenchyme is thicker compared to controls
• smaller alveolar spaces at E18.5




Genotype
MGI:5298646
cx3
Allelic
Composition
Dppa2tm1.1Yam/Dppa2tm1.1Yam
Dppa4tm1.1Yam/Dppa4tm1.1Yam
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2tm1.1Yam mutation (1 available); any Dppa2 mutation (27 available)
Dppa4tm1.1Yam mutation (2 available); any Dppa4 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at weaning, only 2.9% of pups are double homozygotes
• fewer than expected found at birth
• however, expected numbers are found at E18.5

respiratory system
• at E18.5 the lung mesenchyme is thicker compared to controls
• severity of the increase in thickness is variable
• smaller alveolar spaces at E18.5
• severity of the decrease in size is variable

growth/size/body

reproductive system
N
• surviving adults are fertile





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory