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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Camk2a-Setdb1)1Akba
transgene insertion 1, Schahram Akbarian
MGI:5298876
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:5299161
tg2
 		Tg(Camk2a-Setdb1)1Akba/0 involves: C57BL/6 * SJL MGI:5299143


Genotype
MGI:5299161
cn1
Allelic
Composition		 Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (41 available)
Tg(Camk2a-Setdb1)1Akba mutation (0 available)
Tg(Nes-cre)1Atp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:178512 )
• mice die between 8 and 40 weeks of age

behavior/neurological
decreased locomotor activity ( J:178512 )
• worse than in Mecp2tm1Jae/Y mice

growth/size/body
decreased body weight ( J:178512 )




Genotype
MGI:5299143
tg2
Allelic
Composition		 Tg(Camk2a-Setdb1)1Akba/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:178512 )
N
• mice exhibit normal survival

behavior/neurological
behavior/neurological phenotype ( J:160826 , J:178512 )
N
• mice exhibit normal shock-associated reactivity and memory, novelty-induced locomotion activity, and anxiety-related behaviors (J:160826)
• mice exhibit normal neurological function (J:178512)
abnormal depression-related behavior ( J:160826 )
• mice exhibit increased antidepressive behavior (increased sucrose consumption in an anhedonia test and decreased despair in a forced swim test) compared with wild-type mice
impaired coordination ( J:160826 )
• subtle decrease

nervous system
abnormal excitatory postsynaptic potential ( J:160826 )
• medium spiny neuron excitatory postsynaptic potential is not sensitive to NR2B/Grin2b antagonist unlike wild-type neurons
abnormal NMDA-mediated synaptic currents ( J:160826 )
• mice exhibit accelerated NMDA current desensitization compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory