All Phenotypes Prkdc<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prkdc^m1Btlr
mutation 1, Bruce Beutler
MGI:5299140

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkdc^m1Btlr/Prkdc^m1Btlr	C57BL/6J-Prkdc^m1Btlr	MGI:5301256
hm2	Prkdc^m1Btlr/Prkdc^m1Btlr	involves: C57BL/6J	MGI:5429192

Allelic Composition	Prkdc^m1Btlr/Prkdc^m1Btlr
Genetic Background	C57BL/6J-Prkdc^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^m1Btlr mutation (1 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system physiology ( J:178522 )

• mice exhibit a low T-independent IgM response and a null T-dependent IgG response

Allelic Composition	Prkdc^m1Btlr/Prkdc^m1Btlr
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^m1Btlr mutation (1 available); any Prkdc mutation (418 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased B cell number ( J:185495 )

• severe B cell deficiency

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

hematopoietic system