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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tln1tm1.1Bpet
targeted mutation 1.1, Brian G Petrich
MGI:5299185
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tln1tm1.1Bpet/Tln1tm4.1Crit
Tg(Pf4-icre)Q3Rsko/0
involves: 129P2/OlaHsd * C57BL/6 MGI:5299187


Genotype
MGI:5299187
cn1
Allelic
Composition
Tln1tm1.1Bpet/Tln1tm4.1Crit
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pf4-icre)Q3Rsko mutation (1 available)
Tln1tm1.1Bpet mutation (0 available); any Tln1 mutation (146 available)
Tln1tm4.1Crit mutation (2 available); any Tln1 mutation (146 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• fibrogen binding is reduced compared to wild-type cells
• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice
• however, binding in the presence of manganese is normal
• clot retraction is impaired compared to in wild-type mice
• however, clot retraction in the presence of manganese is normal

hematopoietic system
• fibrogen binding is reduced compared to wild-type cells
• platelets exhibit defective agonist induced platelet integrin activation compared with wild-type mice
• however, binding in the presence of manganese is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory