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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Phb2tm2.1Katz
targeted mutation 2.1, Benita S Katzenellenbogen
MGI:5299189
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Phb2tm2.1Katz/Phb2+
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5299191
cn2
 		Phb2tm2.1Katz/Phb2tm2.1Katz
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129S1/Sv * 129X1/SvJ MGI:5299193
cn3
 		Phb2tm2.1Katz/Phb2+
Tg(Wap-cre)11738Mam/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5299192
cn4
 		Phb2tm2.1Katz/Phb2tm2.1Katz
Tg(Wap-cre)11738Mam/0 		involves: C57BL/6 * SJL MGI:5299194


Genotype
MGI:5299191
cn1
Allelic
Composition		 Phb2tm2.1Katz/Phb2+
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland duct morphology ( J:178347 )
• during puberty, mammary ductal morphogenesis is accelerated with increased ductal length compared to in control mice
• the number of terminal end buds is increased compared to in control mice

integument
abnormal mammary gland duct morphology ( J:178347 )
• during puberty, mammary ductal morphogenesis is accelerated with increased ductal length compared to in control mice
• the number of terminal end buds is increased compared to in control mice




Genotype
MGI:5299193
cn2
Allelic
Composition		 Phb2tm2.1Katz/Phb2tm2.1Katz
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:178347 )
N
• mice exhibit normal ovarian function, including follicle maturation, ovulation, corpora lutea formation, and estrous cycle

integument
abnormal mammary gland morphology ( J:178347 )
• at 15 weeks, mice exhibit severe defects in mammary gland morphogenesis
abnormal mammary gland duct morphology ( J:178347 )
• during puberty, mammary ductal morphogenesis is severely impaired compared to in control mice
• terminal end buds are very small and not developed compared to in control mice
• at 24 weeks, the ductal network barely invades the fat pad

endocrine/exocrine glands
abnormal mammary gland morphology ( J:178347 )
• at 15 weeks, mice exhibit severe defects in mammary gland morphogenesis
abnormal mammary gland duct morphology ( J:178347 )
• during puberty, mammary ductal morphogenesis is severely impaired compared to in control mice
• terminal end buds are very small and not developed compared to in control mice
• at 24 weeks, the ductal network barely invades the fat pad




Genotype
MGI:5299192
cn3
Allelic
Composition		 Phb2tm2.1Katz/Phb2+
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (24 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nursing ( J:178347 )
• dams support increased weight gain in nursed pups compared with pups nursed by control mice

integument
abnormal milk composition ( J:178347 )
• expression of milk protein genes is increased compared to in control mice

endocrine/exocrine glands
abnormal milk composition ( J:178347 )
• expression of milk protein genes is increased compared to in control mice




Genotype
MGI:5299194
cn4
Allelic
Composition		 Phb2tm2.1Katz/Phb2tm2.1Katz
Tg(Wap-cre)11738Mam/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm2.1Katz mutation (0 available); any Phb2 mutation (24 available)
Tg(Wap-cre)11738Mam mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nursing ( J:178347 )
• dams do not support the growth of nursing pups who exhibit reduced weight gain compared with pups nursed by control mice

endocrine/exocrine glands
abnormal involution of the mammary gland ( J:178347 )
• dramatically accelerated
abnormal mammary gland growth during lactation ( J:178347 )
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice
abnormal mammary gland alveolus morphology ( J:178347 )
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice
• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice
abnormal milk composition ( J:178347 )
• expression of milk protein genes is decreased compared to in control mice
increased mammary gland apoptosis ( J:178347 )
• in differentiated mammary epithelial cells during lactation

integument
abnormal involution of the mammary gland ( J:178347 )
• dramatically accelerated
abnormal mammary gland growth during lactation ( J:178347 )
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice
abnormal mammary gland alveolus morphology ( J:178347 )
• at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice
• 3 days after weaning, mice exhibit collapse of alveoli unlike control mice
abnormal milk composition ( J:178347 )
• expression of milk protein genes is decreased compared to in control mice
increased mammary gland apoptosis ( J:178347 )
• in differentiated mammary epithelial cells during lactation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory